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GI-2101 - TRANSLATIONAL INVESTIGATION GROUP OF CRITICAL PATIENT. MECHANISM OF CELL INJURY   [4760]

Group info
Code: GI-2101
Short Name: Celular injury in critical patient
Name: Translational Investigation Group of Critical Patient. Mechanism of cell injury
Department: Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
Contact: ALVAREZ ESCUDERO, JULIAN - julian.alvarez@usc.es
Telf.

Research field
  • 1) Sepsis research: identification of clinical, molecular and genetic risk factors to develop complications and mortality associated to this disease, a syndrome in ICUs with high prevalence and increasing incidence. 2) Identification and characterization of cellular effects of anaesthetics: cytoprotective mechanisms, inflammatory mediators, oxydative stress. 3) Identification of prognostic factors, therapeutic targets and characterization of sepsis-associated encephalopathy, the most frequent encephalopathy in ICUs without any current specific treatment.
Technology services
  • Cellular cultures: HUVEC endothelial cells, neurons, astrocytes, monocytes. In vitro and in vivo sepsis models Real-time PCR and thermocyclers. Enzyme-linked immunosorbent assays. DNA and plasma bank of critical patients Animal surgery Confocal microscopy Mass spectrometry Vital signs measured by invasive and non-invasive techniques Anesthetic effects assessed by electroencephalography-based monitoring: Bi-spectral Index®, Entropy® Web-based technology database, for patients registry and analysis. Controlled hypothermia techniques.
Key words
  • sepsis, cytoprotection, anaesthetics, inflammation, genetics
Researchers
Name Position PIID ORCID Contact:
ALVAREZ ESCUDERO, JULIANCoordinador582140000-0002-2518-0891E-Mail: julian.alvarez@usc.es
BUSTAMANTE MONTALVO, MANUEL PEDROMembro
CORTIÑAS DIAZ, JULIO ANTONIOMembro
RODRIGUEZ GARCIA, JAIME JOSEMembro
RODRIGUEZ PEREZ, ALFONSOMembro
TABOADA MUÑIZ, MANUELMembro
VEIRAS DEL RIO, SONIAMembro
IP Principal Investigator, IFP Training Research, PA Supporting Researchers and Technicians
External collaborators
Name Institution
SONIA VEIRAS DEL RIO  Complejo Hospitalrio Universitario Santiago de Compostela
Pablo Lopez Paia  Complejo Hospitalario Universitario de Santiago de Compostela
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