Over the last few years there has been an enormous development in biological research and in the field of Chemical Biology. Some of the most important topics in biology-applied chemical research are the development of sensors for identification and monitoring of protein-protein and protein-DNA interactions, the design and synthesis of simple chemical models of complex biological systems, and the development of chemical tools for biological research, such as new imaging strategies or caged compounds for spatial and temporal control of the biological response. Our research is characterized by a multi-disciplinary problem-solving approach including organic synthesis, spectroscopy, biochemistry and computational chemistry, applied to expand the available chemical tools for the study of complex molecular processes of biological systems and develop model systems for the study of protein-DNA intereactions.